Imaging Physics

In collaboration with Siemens Healthineers and members of the UCLA MRRL, advanced MRI imaging techniques are continuously implemented at the BTIL with the goal of developing novel imaging contrasts and biomarkers to improve the characterization of malignant brain lesions and tumors, both for clinical research and diagnostic applications. To improve patient comfort and enrich the value of clinical exams, a second focus lies in reducing total image acquisition time by applying multi-slice and multinuclear interleaving acquisition techniques. Our endeavor of incorporating state-of-the-art techniques into our workflow will further our mission of pioneering diagnosis for brain malignancies and tumors.

Chemical Exchange Saturation Transfer (CEST)

Our research delves into the domain of Chemical Exchange Saturation Transfer (CEST) sequences, with the aim of enhancing the sensitivity and specificity of imaging certain molecules. This novel approach contributes to the detailed characterization of brain tumors and their microenvironment.​​

Sodium imaging

Evaluation of brain total sodium content offers unique insights into cellular integrity and viability. Although challenging to perform at 3T, the sodium gradient between extracellular and intracellular spaces makes it an excellent probe for Na+/K+-ATPase activity disruption. Sodium imaging therefore offers a great potential for evaluating brain diseases and tumor therapeutic response. ​​